| | N-of-1 | Crossover | Parallel Group
| Single Group, etc. | | Statistical intent (superiority, non-inferiority, equivalence) | √ | √ | √ | N/A | | Sequence generation (random, non-random) | | | | | | Allocation method (a, b, c, d, e) | | | | | Blinding/Masking (yes/no of each of: participant,
investigator, outcomes assessor, statistician) | | | | | Control group type (active, placebo, sham, usual care,
dose comparison, historical) | | | | | | Study phase (Phase 0, I, I/II, II, II/III, III, IV) | | | | |
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