Example: Cohort Study - Framingham

Lead Author(s): Jeff Martin, MD

Framingham Study - Impact of Diabetes

The Framingham Study reports on the impact of diabetes in myocardial infarction:

"The impact of diabetes on recurrent myocardial infarction (MI) and fatal coronary heart disease was examined in survivors of an initial MI using 34-year follow-up data in the Framingham Study. Among nondiabetic patients, the risk of fatal coronary heart disease was significantly lower in women compared with men (relative risk, 0.6). In the presence of diabetes, however, the risk of recurrent MI in women was twice the risk in men. In addition, the effect of diabetes doubled the risk of recurrent MI in women (relative risk, 2.1) but had an insignificant effect in men."

Oldest Cohort Study

The Framingham Study is the oldest and best known cohort study in the United States. It is the classic cohort study of coronary heart disease.

The study first elucidated the major risk factors for coronary heart disease:

First Study

Second Study

Third Study


Abbott, R. D., Donahue, R. P., Kannel, W. B., & Wilson, P. W. (1988). The impact of diabetes on survival following myocardial infarction in men vs women. The Framingham Study. Jama, 260 (23), 3456-3460.