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Image %LIGHTBOX{ image="lancetdata.jpg" thumbnail="tn_lancetdata.jpg" caption="Lancet Data Graphic"}% Click to enlarge data.
Title Efficacy of T4N5 The Lancet Data - Code Expands
Graph_Subgroup General Principles
Code Added Yes
Description The cumulative number of AK and BCC lesions for each subject. The y-axis is truncated which hides the fact that Subj. 19 had 193 lesions (detected in alternate views of the data set).
Contributor/Email Mat Soukup (email: Mat.Soukup@fda.hhs.gov)
Background * Data is publicly available on journal website (reference below).
* XP is life-threatening disease occurring in approximately 1 out of 250,000 people in the US. Average age of developing skin cancer is 8 years.
* Study objective is to see if T4N5 reduces number of AK and BCC lesions.
* Study enrolled 30 subjects, 20 randomized to T4N5.
Special Considerations
Date Original
Original Date 2007
Modified Date
Use/Suitability Presentation
Software Program R
Software
R-Code - Attachment Lancet Data - Attached
R-Code


lan <- read.csv("//cdsnas/oebdbdms/Graphics/DataSets/lancetdata.txt")<br />
c1 <- with(lan, visit1)<br />c2 <- with(lan, visit1+visit2)<br />c3 <- with(lan, visit1+visit2+visit3)<br />c4 <- with(lan, visit1+visit2+visit3+visit4)<br />c5 <- with(lan, visit1+visit2+visit3+visit4+visit5)<br />c6 <- with(lan, visit1+visit2+visit3+visit4+visit5+visit6)<br />
csum <- c(lan$base,c1,c2,c3,c4,c5,c6)<br />ID2 <- paste("subj. ", rep(lan$id, 7),sep="")<br />age2 <- with(lan, rep(age, 7))<br />ctry2 <- with(lan, rep(country,7))<br />trt2 <- with(lan, rep(trt, 7))<br />month2 <- rep(c(0,3,6,9,12,13,18), each=29)<br />
#BCC data
bat <- read.csv("//cdsnas/oebdbdms/Graphics/DataSets/lancetBCC.txt")<br />
b1 <- with(bat, visit1)<br />b2 <- with(bat, visit1+visit2)<br />b3 <- with(bat, visit1+visit2+visit3)<br />b4 <- with(bat, visit1+visit2+visit3+visit4)<br />b5 <- with(bat, visit1+visit2+visit3+visit4+visit5)<br />b6 <- with(bat, visit1+visit2+visit3+visit4+visit5+visit6)<br />
bcc <- c(bat$base,b1,b2,b3,b4,b5,b6)<br />idb <- paste("subj. ", rep(bat$id, 7), sep="")<br />trtb <- with(bat, rep(trt, 7))<br />monthb <- rep(c(0,3,6,9,12,13,18), each=29)<br />
# Combine BCC and AK
lesions <- c(csum, bcc)<br />trts <- factor(paste(c(rep('AK',203),rep('BCC',203)), c(trt2, trtb), sep="-"),<br />levels=c('AK-1','AK-2','BCC-1','BCC-2'),
labels=c('Placebo-AK','T4N5-AK','Placebo-BCC',
'T4N5-BCC'))
lesi <- factor(c(rep('AK',203), rep('BCC',203)), labels=c('AK','BCC'))<br />trti <- factor(c(trt2,trtb), levels=1:2, labels=c('Placebo','T4N5'))<br />
ids <- c(ID2, idb)<br />amonth <- c(month2, monthb)<br />
aat <- data.frame(id=ids,trt=trts, month=amonth, lesions, trti, lesi)<br />
#png('C:/Research/Graphics/Graphs4Display/webpages/classes/pages/images/lancetdata.png',
# width=700, height=700)

new.back <- trellis.par.get("background")<br />new.back$col <- "white"<br />newcol <- trellis.par.get("superpose.symbol")<br />newcol$col <- c('green4','blue','red','black')<br />newcol$pch <- c(16,1,4,8)<br />newline <- trellis.par.get("superpose.line")<br />newline$col <- c('green4','blue','red','black')<br />trellis.par.set("background", new.back)
trellis.par.set("superpose.symbol", newcol)
trellis.par.set("superpose.line", newline)
strip <- trellis.par.get("strip.background")<br />strip$col <- 'gray91'<br />trellis.par.set("strip.background",strip)

xyplot(lesions~month|id, groups=trt, data=aat, type='s',
xlab='Month',
ylab='Sum of New Lesions',
ylim=c(-5,100),
scales=list(x=list(at=c(0,3,6,9,12,18),
labels=as.character(c(0,3,6,9,12,18)))),
col=c('navy','hotpink4','deepskyblue2','red'),
lty=c(1,1,1,1),
key=list(lines=list(type='l', lty=c(1,1,1,1),
col=c('navy','hotpink4','deepskyblue2','red')),
text=list(lab=c('Placebo-AK','T4N5-AK',
'Placebo-BCC','T4N5-BCC'),
col=c('navy','hotpink4','deepskyblue2','red')),
columns=2, title='Treatment-Lesion'))
#dev.off()

SAS-Code - Attachment
SAS-Code
Stata-Code - Attachment
Stata-Code
Other Code - Attachment
Other Code
Keywords efficacy, orphan indication, XP, Poisson regression
OPTIONAL FIELDS
References Yarosh D, Klein J, O\x92Connor A, Alas L, et al. Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xero-derma pigmentosum: A randomized study. The Lancet, Vol. 357, Issue 9260, March 2001, pages 926-929.


Datasets
Data
Attached Data
CATEGORIZATIONS
Classification-Evaluation Efficacy
Classification-Graph Type Scatterplot
Graph_Type Scatterplot
Variable Relationship Continuous versus Categorical Conditioned
Data Types Categorical and Continuous
Special Cases
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Reference Image LancetEfficacy_reference_200.jpg
This topic: CTSpedia > WebHome > StatGraphHome > ContributeGraphics > StatGraphTopic009
Topic revision: 30 Mar 2012, MaryBanach
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