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Image %LIGHTBOX{ image="vitals_mean_profile_by_time.jpg" thumbnail="vitals_mean_Reference_200.jpg" caption="Blood Pressure Changes" }% Click on image to enlarge.
Title Vital Signs: Mean Change by Time and Treatment
Description This figure plots mean changes and 95% confidence intervals for standing and supine systolic, diastolic, and pulse rate on one sheet in order to observe any gross dose related trends in any of the six domains.
Contributor/Email Rich Anziano (Richard.J.Anziano@Pfizer.com)
Background
Special Considerations
Original Date
Modified Date
Use/Suitability Exploration, Presentation
Software Program
Software PPD Patient Profiles (CrossGraphs)
R-Code - Attachment
R-Code
SAS-Code - Attachment
SAS-Code
Stata-Code - Attachment
Stata-Code
Other Code - Attachment
Other Code
Keywords
OPTIONAL FIELDS
References
Datasets
Data This vital signs data was simulated from a typical dose escallation FIH trial. Vital Signs data (Systolic/Diastolic BP, and Pulse) were measured at screening, pre-dose, and at 1, 2, 4, 6, 12, 24 and 48 hours following a single dose. Collections were made in the supine and standing positions. BMI, Height, and Weight were also collected at screening.

There are 56 subjects in the dataset. If there were no missing data there would have been 56 subjects x 7 timepoints x 2 positions per timepoint x 3 vs collections (systolic, diastolic, bp) = 2352 observations in the post screening phase. For BMI, Height and Weight which was only collected at screening, there would be 56 observations corresponding to one obs per subject.

Dataset Links:
SAS Transport Dataset:
Included as attachment - vitals.dst

Comma Delimited ASCII:
Included as attachment - vitals.dat
* Click on hyperlink for Comma Delimited ASCII File
Attached Data
CATEGORIZATIONS
Classification-Evaluation Safety
Classification-Graph Type
Variable Relationship Continuous versus Continuous
Data Types Continuous
Special Cases
Disclaimer The views expressed within CTSpedia are those of the author and must not be taken to represent policy or guidance on the behalf of any organization or institution with which the author is affiliated.
Permission Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF ERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT OLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
Reference Image vitals_mean_Reference_200.jpg
This topic: CTSpedia > WebHome > StatGraphHome > ContributeGraphics > StatGraphTopic021
Topic revision: 24 Feb 2012, MaryBanach
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