Writing the Research Plan Section: Specific Aims

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Slide 1: Writing a competitive mentored K award grant application

Slide 2: Section 4: Research Plan

Slide 3: Strategies that work & Mistakes to avoid

Slide 4: Strategies that work & Mistakes to avoid (cont'd)

Slide 5: Strategies that work/Mistakes to avoid (cont'd)

Slide 6: Strategies that work/Mistakes to avoid (cont'd)

Slide 7: Distinctive Features of a Research Plan for a Mentored K award

Slide 8: Specific Aims

Slide 9: Specific Aims (cont'd)

Slide 10: Specific Aims

Slide 11: Integration of research plan with career development plan

At the end of the Specific Aims section, describe how the research plan is integrated with the career development plan (give concrete examples).

"Each of these specific aims is designed to provide me with the necessary skills and experiences to become an independent health services researcher. My long-term goals are two-fold: (1) to develop interventions to help clinicians better prescribe warfarin, and (2) to better describe risk factors for poor warfarin outcomes in an effort to improve existing risk stratification tools.

In Aim 1, the research plan will provide experience in longitudinal data analysis, propensity score analysis, outcomes assessment, cost-benefit analysis, and pharmacoepidemiology. Aim 2 will provide experience in prospective data collection, development of an independent cohort, and assessment of patient functional status and frailty. Aim 3 will provide experience developing a decision support intervention and obtain pilot data for the subsequent intervention study.

Additionally, each of these aims clearly comprises a necessary precursor for my anticipated R01 application. For example, Aims 1 and 2 will provide crucial data on the risk factors, rates, and outcomes of warfarin-associated hemorrhage. Aim 3 will incorporate these data into a user-friendly decision tool that helps clinicians balance the risks and benefits of warfarin.

Thus, this study will provide important pilot data in preparation for a larger practice-based intervention study investigating the effect of this decision tool on clinician prescribing of warfarin, patient understanding of the risks and benefits of warfarin, and on stroke and hemorrhage outcomes.